At the time of ovulation, a fresh prepared semen sample is introduced by a fine catheter, gently through cervical opening up into the uterine cavity. This procedure is called IUI. It is indicated for couples with minor male factor subfertility with patent fallopian tubes and unexplained infertility. To maximize the treatment outcome, ovarian stimulation with either oral medication or injections given and follicles monitored to ensure the best timing for insemination. Usually not more than 3 follicles are generated to minimize the risks of multiple pregnancy. The chance of pregnancy is 10-15%. If the patient fails to conceive after four cycles of treatment, it is advisable to consider other modalities of treatment.

IUI Procedures
1. Stimulating two or three eggs to mature	* Usually gonadotrophins are used
2. Monitoring the growth of follicles; adjusting drug dosage; prevention serious side effects	* Transvaginal ultrsound * Blood hormone level
3. On ovulation day, collected fresh semen sample to prepare and inseminate
4. Testing for pregnancy